Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8397212 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL8392259 | 0.89 | ALDH1A1 (0.44) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL8397185 | 0.88 | ALDH1A1 (0.43) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| Iodide SCHEMBL11163928 | 0.79 | MAPT (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL11163912 | 0.78 | KMT2A (0.65) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL8392821 | 0.78 | GAA (0.59) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| Iodide SCHEMBL11169901 | 0.77 | ALDH1A1 (0.46) | SMN1; SMN2KMT2AALDH1A1HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL8396116 | 0.77 | GAA (0.58) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL8392998 | 0.77 | HDAC1 (0.44) | SMN1; SMN2MAPK1PKMKDM4EMAPT | |
| SCHEMBL8392883 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |