Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | F2R | P25116 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8393848 | 0.99 | POLB (0.53) | POLBF2RSMN1; SMN2TP53NPC1 | |
| SCHEMBL8392632 | 0.89 | POLB (0.57) | POLBF2RSMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8397107 | 0.88 | POLB (0.56) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8394989 | 0.84 | POLB (0.57) | POLBSMN1; SMN2RAB9AALDH1A1HTT | |
| SCHEMBL8395561 | 0.84 | MAPT (0.68) | POLBSMN1; SMN2NPC1RAB9AUSP2 | |
| SCHEMBL8481138 | 0.83 | POLB (0.53) | POLBF2RSMN1; SMN2TP53NPC1 | |
| Hydrochloric Acid SCHEMBL8392011 | 0.83 | MAPT (0.67) | POLBSMN1; SMN2NPC1RAB9AUSP2 | |
| SCHEMBL8392821 | 0.82 | GAA (0.59) | POLBSMN1; SMN2TP53RAB9AALDH1A1 | |
| SCHEMBL10975643 | 0.81 | F2R (0.73) | POLBF2RTP53RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8396116 | 0.81 | GAA (0.58) | POLBSMN1; SMN2TP53RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |