SCHEMBL839335

SCHEMBL839335

CCOC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)c1ccco1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.52
ACACB O00763 1/20 0.50
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
TSHR P16473 2/20 0.47
ALDH1A1 P00352 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
ABCG2 Q9UNQ0 1/20 0.46
HDAC1 Q13547 2/20 0.45
HDAC6 Q9UBN7 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL840367 1.00 CTSL (0.52) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL838462 1.00 CTSL (0.52) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL839112 0.90 CTSL (0.62) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL839803 0.90 CTSL (0.62) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL838893 0.90 CTSL (0.62) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL839754 0.88 CTSL (0.52) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL839454 0.88 CTSL (0.52) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL838601 0.88 CTSL (0.52) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL840332 0.87 ACACB (0.54) CTSLACACBCYP1A2CYP3A4CYP2D6
SCHEMBL27733365 0.84 CTSL (0.47) CTSLACACBCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8143052-B2 Process for preparing optically active (S or R)-α amino acid and (R or S)-α amino acid ester in one phase organic reaction medium UBE INDUSTRIES, LTD. (JP) 2012-03-27 US disclosed