SCHEMBL8393441

SCHEMBL8393441

CC(=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 1/20 0.62
NAALAD2 Q9Y3Q0 1/20 0.58
ACE P12821 9/20 0.57
MME P08473 7/20 0.57
CPA1 P15085 1/20 0.57
ACE2 Q9BYF1 1/20 0.57
SLC7A5 Q01650 1/20 0.53
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
MMP9 P14780 1/20 0.50
MMP8 P22894 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8393434 1.00 FOLH1 (0.62) FOLH1NAALAD2ACEMMECPA1
SCHEMBL346687 0.88 FOLH1 (0.59) FOLH1NAALAD2ACEMMECPA1
SCHEMBL8021425 0.88 FOLH1 (0.59) FOLH1NAALAD2ACEMMECPA1
SCHEMBL596491 0.87 MME (0.59) NAALAD2ACEMMECPA1ACE2
Acetyl Tyrosine SCHEMBL313539 0.87 FOLH1 (0.66) FOLH1NAALAD2ACEMMECPA1
Acetyl Tyrosine SCHEMBL1204300 0.87 FOLH1 (0.66) FOLH1NAALAD2ACEMMECPA1
Acetyl Tyrosine SCHEMBL8977600 0.87 FOLH1 (0.66) FOLH1NAALAD2ACEMMECPA1
SCHEMBL596493 0.87 MME (0.59) NAALAD2ACEMMECPA1ACE2
Acetyl Tyrosine SCHEMBL8977601 0.87 FOLH1 (0.66) FOLH1NAALAD2ACEMMECPA1
Acetyl Tyrosine SCHEMBL321220 0.87 FOLH1 (0.66) FOLH1NAALAD2ACEMMECPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6008252-A Method for increasing muscle mass in a mammal BEALE PAXTON K (US) 1999-12-28 US claimed
US-6008252-A Method for increasing muscle mass in a mammal BEALE PAXTON K (US) 1999-12-28 US disclosed