Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944446 | 0.99 | EPHX2 (0.54) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8395679 | 0.99 | EPHX2 (0.54) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8393802 | 0.97 | HRH4 (0.49) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8944423 | 0.94 | HRH4 (0.51) | EPHX2HRH4HRH3MEN1KMT2A | |
| SCHEMBL8944438 | 0.92 | HRH4 (0.58) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8397004 | 0.92 | HRH4 (0.55) | EPHX2HRH4HRH3MEN1KMT2A | |
| SCHEMBL8393364 | 0.91 | HRH4 (0.56) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8391877 | 0.91 | HRH4 (0.60) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8396568 | 0.91 | HRH4 (0.56) | EPHX2HRH4HRH3BCHEMEN1 | |
| SCHEMBL8394113 | 0.91 | HRH4 (0.60) | EPHX2HRH4HRH3BCHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |