Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.60 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391877 | 1.00 | HRH4 (0.60) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8944438 | 0.99 | HRH4 (0.58) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8393787 | 0.96 | HRH4 (0.56) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8393953 | 0.94 | HRH4 (0.61) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8391909 | 0.94 | HRH4 (0.61) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8393228 | 0.94 | HRH4 (0.58) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8391620 | 0.93 | HRH4 (0.59) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8944446 | 0.92 | EPHX2 (0.54) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8395679 | 0.92 | EPHX2 (0.54) | HRH4HRH3NAAARAB9ANPC1 | |
| SCHEMBL8393530 | 0.91 | EPHX2 (0.52) | HRH4HRH3NAAARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |