Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.43 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.43 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.43 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.43 |
| ▸ | GAPDH | P04406 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391343 | 1.00 | POLB (0.49) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL10024427 | 0.89 | POLB (0.46) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL9771282 | 0.88 | USP2 (0.55) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL14405371 | 0.87 | USP2 (0.54) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL7795410 | 0.87 | LGALS3 (0.53) | POLBUSP2MEN1KMT2APTPN1 | |
| SCHEMBL7798910 | 0.87 | LGALS3 (0.53) | POLBUSP2MEN1KMT2APTPN1 | |
| SCHEMBL16756804 | 0.86 | POLB (0.50) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL15959273 | 0.86 | PTPN1 (0.54) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL21894771 | 0.86 | POLB (0.50) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL12140889 | 0.86 | PTPN1 (0.54) | POLBUSP2MEN1KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886167-A | NUCLEOSIDE ANTIBIOTIC; A COFORMYCIN DERIVATIVE; ENZYME INHIBITOR; USEFUL FOR TREATING LYMPHOCYTIC LEUKEMIA CAUSED BY ADENOSINE DEAMINASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5831072-A | Process for the preparation of 2'-deoxy-2'-halocoformycins or steroisomers thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1998-11-03 | — | — | US | disclosed |
| US-5773607-A | MULTISTAGE PROCESS WITH REDUCTION AND CYCLIZATION FOR FORMATION OF ENZYME INHIBITORS OF ADENOSINE DEAMINASE AS ANTITUMOR AGENTS AND ANTICARCINOGENIC AGENTS AND BACTERICIDES | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0643069-B1 | 2'-DEOXY-2'-FLUOROCOFORMYCIN AND STEREOISOMERS THEREOF | ZAIDAN HOJIN BISEIBUTSU (JP) | 1997-03-05 | — | — | EP | disclosed |
| EP-0643069-A1 | 2'-DEOXY-2'-FLUOROCOFORMYCIN AND STEREOISOMERS THEREOF | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-03-15 | — | — | EP | disclosed |