LGALS3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL176296	1.00	20/20
SCHEMBL176329	0.76	20/20
SCHEMBL176281	0.76	20/20
SCHEMBL177372	0.74	20/20
SCHEMBL175953	0.71	19/20
Thiodigalactoside (SCHEMBL116443)	1.00	11/20
SCHEMBL176226	0.49	9/20
SCHEMBL540778	0.66	8/20
SCHEMBL137947	0.58	8/20
SCHEMBL137948	0.58	8/20
SCHEMBL151041	0.58	8/20
SCHEMBL151685	0.58	8/20
SCHEMBL416020	0.58	8/20
SCHEMBL103814	0.56	8/20
SCHEMBL117333	0.66	7/20
SCHEMBL769001	0.65	7/20
SCHEMBL181379	0.63	7/20
SCHEMBL715283	0.61	7/20
SCHEMBL715284	0.61	7/20
SCHEMBL701054	0.40	7/20

Clinical trials — most relevant to LGALS3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.	PHASE3	UNKNOWN
A Phase 2b Study of GCS-100 in Patients With Chronic Kidney Disease Caused by Diabetes	PHASE2	UNKNOWN
A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease	PHASE2	COMPLETED
Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction	PHASE2	UNKNOWN
Effect of Modified Citrus Pectin on PSA Kinetics in Biochemical Relapsed PC With Serial Increases in PSA	PHASE2	COMPLETED
A Phase 2 Extension Study of Study GCS-100-CS-4002	PHASE2	COMPLETED
TB006 for Autism Spectrum Disorder	PHASE2	RECRUITING
Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors	PHASE2	COMPLETED
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies	nan	COMPLETED
Galectin and Respiratory Weaning	nan	UNKNOWN
Galectin-3 Blockade in Patients With High Blood Pressure	nan	COMPLETED
Effect of Low-Glycemic Index Mediterranean Diet on AGEs	nan	COMPLETED
Galectin-3 for Thromboembolic Formation in Patients With Atrial Fibrillation CHA₂DS₂-VASc Scoring	nan	UNKNOWN
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis	nan	UNKNOWN
Galectin-3 Binding Protein in Cardiovascular Disease and Chronic Heart Failure	nan	COMPLETED
Galectin-3 as a Biomarker in Patients With Chagas Disease	nan	COMPLETED
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia	nan	UNKNOWN
Galectin-3 in Septic and Non-septic Acute Kidney Injury	nan	UNKNOWN
Urinary G3BP as a Novel Biomarker in Lupus Nephritis	nan	NOT_YET_RECRUITING
The Diagnostic Value of Serum Oncostatin M and Galactin 3 as Biomarkers in Diagnosis of Ulcerative Colitis Disease	nan	NOT_YET_RECRUITING
A Wearable Device and AI-Supported Diet and Exercise Intervention	nan	RECRUITING
Serum Galectin-3 as a Marker of Human Papillomavirus Infection	nan	COMPLETED
Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter	nan	COMPLETED
Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients	nan	UNKNOWN
Biomarkers for Risk Stratification After STEMI	nan	UNKNOWN
Galectin-3 in Patients With Endometriosis	nan	UNKNOWN
Measuring Immune Tolerance to Predict Miscarriage or Failed Embryo Transfer	nan	COMPLETED
Novel Cardiovascular Biomarkers in Patients With Kidney Disease	nan	NOT_YET_RECRUITING
Correlational Study on the Biomarkers Application to the Prediction and Diagnosis of Cardiovascular Diseases	nan	COMPLETED
Influence of Periodontitis and Coronary Heart Disease on Galectin-3	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LGALS3 binder may also engage these)

Protein	Name	Similarity
P47953	—	1.000	P47953 →
P47845	—	1.000	P47845 →
P16110	—	1.000	P16110 →
P08699	—	1.000	P08699 →
P38486	—	0.997	P38486 →
PEF1	Peflin	0.974	landscape →
Q641Z8	—	0.971	Q641Z8 →
P19198	—	0.971	P19198 →
Q8BFY6	—	0.970	Q8BFY6 →
ANXA7	Annexin A7	0.969	landscape →
Q5PQ53	—	0.969	Q5PQ53 →
Q2QY10	—	0.968	Q2QY10 →
LGALS4	Galectin-4	0.968	landscape →
Q8K419	—	0.968	Q8K419 →
Q4R5L5	—	0.968	Q4R5L5 →
Q29058	—	0.968	Q29058 →
O08573	—	0.968	O08573 →
Q8VDM6	—	0.967	Q8VDM6 →
P97840	—	0.967	P97840 →
P27214	—	0.966	P27214 →
Q5ZK05	—	0.966	Q5ZK05 →
HNRNPUL1	Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.966	landscape →
Q2TA49	—	0.965	Q2TA49 →
Q92125	—	0.965	Q92125 →
P33477	—	0.965	P33477 →
ANXA11	Annexin A11	0.965	landscape →
P0CM58	—	0.965	P0CM58 →
Q4LBC8	—	0.965	Q4LBC8 →
Q8W4L0	—	0.965	Q8W4L0 →
P0CM59	—	0.964	P0CM59 →