SCHEMBL8395145

SCHEMBL8395145

CCCCCCNC(=O)C1([NH])CCCCC1

nearest known ligand 0.55

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 6/20 0.55
NAAA Q02083 1/20 0.49
EPHX1 P07099 12/20 0.48
EPHX2 P34913 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8396618 1.00 SPHK1 (0.55) SPHK1NAAAEPHX1EPHX2
SCHEMBL8395995 1.00 SPHK1 (0.55) SPHK1NAAAEPHX1EPHX2
SCHEMBL8394580 0.93 SPHK1 (0.46) SPHK1NAAAEPHX1EPHX2
SCHEMBL29306660 0.79 SPHK1 (0.50) SPHK1NAAAEPHX1EPHX2
SCHEMBL4678180 0.76 SPHK1 (0.54) SPHK1NAAAEPHX1
SCHEMBL26017783 0.75 SPHK1 (0.57) SPHK1NAAAEPHX1
Cyclohexane SCHEMBL5496549 0.74 EPHX1 (0.86) NAAAEPHX1EPHX2
SCHEMBL16618457 0.74 SPHK1 (0.59) SPHK1NAAAEPHX1
SCHEMBL3427647 0.73 SPHK1 (0.54) SPHK1NAAAEPHX1
SCHEMBL21941459 0.73 SPHK1 (0.54) SPHK1NAAAEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5864043-A CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST KARL THOMAE GMBH (DE) 1999-01-26 US disclosed
US-5614519-A (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists KARL THOMAE GMBH (DE) 1997-03-25 US disclosed
US-5602127-A ADMINISTERING TO TREAT HYPERTENSION KARL THOMAE GMBH (DE) 1997-02-11 US disclosed
US-5594003-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1997-01-14 US disclosed
US-5591762-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
US-5541229-A ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
US-5459147-A Angeotensin-antagonistic effects; hypotensive, antiischemic, and antidiabetic agents, treating glaucoma DR. KARL THOMAE GMBH (DE) 1995-10-17 US disclosed