Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396518 | 0.92 | CHRM5 (0.38) | GRM2ADORA2AADORA2BADORA1KCNH2 | |
| SCHEMBL8393938 | 0.92 | GRM2 (0.35) | GRM2ADORA2AADORA2BADORA1KCNH2 | |
| SCHEMBL8392902 | 0.90 | CHRM5 (0.41) | NPSR1KDM4E | |
| SCHEMBL8394000 | 0.90 | CHRM5 (0.41) | NPSR1KDM4E | |
| SCHEMBL8393989 | 0.88 | ADORA2A (0.38) | GRM2ADORA2AADORA2BADORA1KCNH2 | |
| SCHEMBL8392214 | 0.82 | GRM2 (0.35) | GRM2ADORA2AADORA2BADORA1KCNH2 | |
| SCHEMBL8391452 | 0.82 | CHRM5 (0.36) | GRM2ADORA2AADORA2BADORA1KCNH2 | |
| SCHEMBL8394841 | 0.81 | CHRM5 (0.39) | ADORA2AADORA2BADORA1NPSR1KDM4E | |
| SCHEMBL8394573 | 0.81 | CHRM5 (0.39) | ADORA2AADORA2BADORA1NPSR1KDM4E | |
| SCHEMBL8391397 | 0.80 | ACHE (0.33) | GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |