SCHEMBL8395335

SCHEMBL8395335

O=CCC(F)(F)CCc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 0.39
FAAH O00519 3/20 0.39
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37
CASP1 P29466 1/20 0.37
HSD17B10 Q99714 1/20 0.37
SIGMAR1 Q99720 2/20 0.36
KEAP1 Q14145 1/20 0.36
GSK3A P49840 1/20 0.36
GSK3B P49841 1/20 0.36
MGLL Q99685 1/20 0.36
FDPS P14324 1/20 0.36
TDP1 Q9NUW8 2/20 0.35
CYP2A6 P11509 1/20 0.35
HTR2A P28223 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12213575 0.75 IDO1 (0.42) CES1FAAHSIGMAR1HTR2ASMN1; SMN2
SCHEMBL2010872 0.74 TDP1 (0.50) CES1FAAHALDH1A1HPGDALOX15
SCHEMBL11781938 0.74 TDP1 (0.50) CES1FAAHALDH1A1HPGDALOX15
SCHEMBL17289084 0.74 ALDH1A1 (0.41) CES1FAAHALDH1A1HPGDALOX15
SCHEMBL8395329 0.73 CES1 (0.46) CES1FAAHALDH1A1KEAP1TDP1
SCHEMBL17288497 0.72 ALDH1A1 (0.39) CES1FAAHALDH1A1HPGDALOX15
SCHEMBL144712 0.72 ALDH1A1 (0.48) CES1FAAHALDH1A1HPGDALOX15
SCHEMBL3535252 0.70 CES1 (0.45) CES1FAAHFDPS
SCHEMBL11827007 0.69 TDP1 (0.44) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL17288716 0.69 CES1 (0.39) CES1FAAHALDH1A1HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5985863-A PHARMACEUTICAL COMPOSITIONS FOR DECREASING THE PRODUCTION OF INTERFERON-GAMMA INDUCING FACTOR (IGIF), AND INTERFERON-GAMMA (IFN-GAMMA) COMPRISING COMPOUND WHICH INHIBITS INTERLEUKIN-1.BETA. CONVERTING ENZYME (ICE) VERTEX PHARMACEUTICALS, INC. (US) 1999-11-16 US disclosed