Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | TYMS | P04818 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892518 | 1.00 | NPC1 (0.56) | NPC1RAB9ACASP3PLAUTYMS | |
| SCHEMBL29892522 | 1.00 | NPC1 (0.56) | NPC1RAB9ACASP3PLAUTYMS | |
| SCHEMBL8042550 | 0.89 | NPC1 (0.54) | NPC1RAB9ACASP3PLAUTYMS | |
| SCHEMBL8060495 | 0.88 | NPC1 (0.53) | NPC1RAB9ACASP3PLAUTYMS | |
| SCHEMBL9125523 | 0.77 | NPC1 (0.58) | NPC1RAB9ACASP3PLAUMGLL | |
| SCHEMBL27786325 | 0.76 | NPC1 (0.57) | NPC1RAB9ACASP3PLAUPTPN1 | |
| SCHEMBL10902168 | 0.76 | TTR (0.53) | RAB9ACA12CA1CA2CA9 | |
| SCHEMBL1339026 | 0.75 | NPC1 (0.62) | NPC1RAB9APOLBHPGD | |
| SCHEMBL9093600 | 0.75 | PLAU (0.55) | NPC1RAB9ACASP3PLAUPTPN1 | |
| SCHEMBL3786444 | 0.75 | NPC1 (0.68) | NPC1RAB9ACASP3PLAUPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228447-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E LIFESCIENCES INC. | 2024-07-11 | — | — | US | disclosed |
| EP-4313959-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E Lifesciences Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120422-A | Substituted naphthyl P38 alpha mitogen-activated protein kinase inhibitors | GEN1E生命科学公司 | 2023-11-24 | — | — | CN | disclosed |
| US-20230227417-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E LIFESCIENCES INC. | 2023-07-20 | — | — | US | disclosed |
| US-20230227417-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E LIFESCIENCES INC. | 2023-07-20 | — | — | US | disclosed |
| WO-2022204046-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E LIFESCIENCES INC. (US) | 2022-09-29 | — | — | WO | disclosed |
| EP-0752986-B1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LTD (GB) | 1999-05-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227417-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | MAPK1, MAPK8, MAPKAPK2 | NPC1 486/4885RAB9A 1915/4885CASP3 2197/4885 |
| US-20240228447-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | MAPK1, MAPK8, MAPKAPK2 | NPC1 486/4885RAB9A 1915/4885CASP3 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.