Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 5/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391120 | 0.98 | EPHX1 (0.46) | EPHX1SMN1; SMN2HPGDLMNANAAA | |
| SCHEMBL8391417 | 0.98 | EPHX1 (0.46) | EPHX1SMN1; SMN2HPGDLMNANAAA | |
| SCHEMBL8394719 | 0.95 | EPHX1 (0.40) | EPHX1SMN1; SMN2HPGDLMNANAAA | |
| SCHEMBL8393821 | 0.91 | — | — | |
| SCHEMBL9040028 | 0.87 | EPHX1 (0.53) | EPHX1SMN1; SMN2NAAAASAH1FKBP1A | |
| SCHEMBL8394197 | 0.85 | EPHX1 (0.56) | EPHX1SMN1; SMN2NAAAASAH1FKBP1A | |
| SCHEMBL8395994 | 0.85 | EPHX1 (0.56) | EPHX1SMN1; SMN2NAAAASAH1FKBP1A | |
| SCHEMBL8393588 | 0.83 | EPHX1 (0.49) | EPHX1SMN1; SMN2NAAAASAH1FKBP1A | |
| SCHEMBL8395658 | 0.82 | EPHX1 (0.43) | EPHX1SMN1; SMN2HPGDLMNANAAA | |
| SCHEMBL8393778 | 0.80 | EPHX1 (0.42) | EPHX1SMN1; SMN2HPGDLMNANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |