Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399011 | 0.93 | KMT2A (0.56) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL8396393 | 0.91 | KDM4E (0.62) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL8400506 | 0.90 | KMT2A (0.61) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL17825434 | 0.90 | OPRL1 (0.66) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL7968189 | 0.86 | KMT2A (0.65) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL6042898 | 0.83 | KMT2A (0.82) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL8397903 | 0.83 | KDM4E (0.61) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL8400209 | 0.80 | KMT2A (0.69) | KMT2AKDM4EOPRL1POLBCCR3 | |
| Hydrochloric Acid SCHEMBL9057167 | 0.78 | POLB (0.65) | KMT2AKDM4EOPRL1POLBCCR3 | |
| SCHEMBL240629 | 0.77 | OPRL1 (0.73) | KMT2AOPRL1POLBCCR3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997048698-A1 | COMPOUNDS HAVING EFFECTS ON SEROTONIN-RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |