Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CCR3 | P51677 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240629 | 0.89 | OPRL1 (0.73) | KMT2AALDH1A1OPRL1POLBCCR3 | |
| SCHEMBL8396393 | 0.88 | KDM4E (0.62) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| SCHEMBL4816046 | 0.88 | ALDH1A1 (0.80) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| SCHEMBL6042898 | 0.87 | KMT2A (0.82) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| SCHEMBL8397903 | 0.87 | KDM4E (0.61) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| Hydrochloric Acid SCHEMBL6288091 | 0.86 | ALDH1A1 (0.78) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| Water SCHEMBL8370326 | 0.86 | KDM4E (0.50) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| SCHEMBL8395687 | 0.86 | KMT2A (0.60) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| SCHEMBL8400506 | 0.85 | KMT2A (0.61) | KMT2AKDM4EALDH1A1OPRL1POLB | |
| SCHEMBL8400209 | 0.84 | KMT2A (0.69) | KMT2AKDM4EALDH1A1OPRL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997048698-A1 | COMPOUNDS HAVING EFFECTS ON SEROTONIN-RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |