Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564728 | 0.93 | GRIA1 (0.61) | GRIA1SIGMAR1BMP1RENGRIA4 | |
| SCHEMBL8393459 | 0.89 | GRIA1 (0.50) | GRIA1SIGMAR1BMP1CYP1A2REN | |
| SCHEMBL24500908 | 0.81 | GRIA1 (0.54) | GRIA1GRIA4KDM1A | |
| SCHEMBL6565156 | 0.81 | GRIA1 (0.54) | GRIA1GRIA4KDM1A | |
| SCHEMBL8395547 | 0.78 | SIGMAR1 (0.48) | SIGMAR1BMP1CYP1A2RENKDM1A | |
| SCHEMBL8392865 | 0.78 | SIGMAR1 (0.48) | SIGMAR1BMP1CYP1A2RENKDM1A | |
| SCHEMBL24429309 | 0.77 | GRIA1 (0.43) | GRIA1 | |
| SCHEMBL13958475 | 0.76 | GRIA1 (0.42) | GRIA1 | |
| SCHEMBL8395062 | 0.76 | GRIA1 (0.42) | GRIA1 | |
| SCHEMBL13565280 | 0.75 | GRIA1 (0.61) | GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |