SCHEMBL8396111

SCHEMBL8396111

C=C1CC(c2ccccc2)OC1=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.53
CYP19A1 P11511 4/20 0.53
AR P10275 2/20 0.53
HSD17B10 Q99714 2/20 0.53
KDM4E B2RXH2 1/20 0.53
ADORA3 P0DMS8 1/20 0.53
ALDH1A1 P00352 1/20 0.46
MAOA P21397 1/20 0.45
PSMB5 P28074 1/20 0.45
TSHR P16473 1/20 0.45
LDHA P00338 3/20 0.44
CYP1A1 P04798 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP1B1 Q16678 1/20 0.43
PLK1 P53350 1/20 0.43
MEN1 O00255 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15084290 0.86 MAOB (0.40) MAOBCYP19A1ARHSD17B10KDM4E
SCHEMBL31048681 0.85 CYP19A1 (0.43) MAOBCYP19A1ARHSD17B10KDM4E
SCHEMBL30528402 0.83 MAOB (0.54) MAOB
SCHEMBL31048559 0.81 LMNA (0.50) MAOBCYP19A1ARHSD17B10KDM4E
SCHEMBL8706199 0.79 MAOB (0.67) MAOBCYP19A1ARHSD17B10KDM4E
SCHEMBL12019823 0.79 MAOB (0.57) MAOBCYP19A1ARADORA3ALDH1A1
SCHEMBL30528493 0.79 SLC6A2 (0.43) CYP19A1KDM4ECYP3A4CYP2D6
SCHEMBL30528494 0.79 TNKS2 (0.41) MAOBCYP19A1ARHSD17B10KDM4E
SCHEMBL4260040 0.79 MAOB (0.60) MAOBCYP19A1ARHSD17B10KDM4E
SCHEMBL12962978 0.78 ROR1 (0.40) MAOBCYP19A1ARHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170174802-A1 COPOLYMER AND MOLDED ARTICLE KURARAY CO., LTD. (JP) 2017-06-22 US disclosed
CN-103304715-B Stereospecific gathers (Beta-hydrocarbyl--alpha-methylene-gamma-butyrolactone) and multipolymer thereof HUAIHUA UNIVERSITY (CN) 2016-01-20 CN disclosed
CN-103304715-A Stereoregular poly (beta-alkyl-alpha-methylene gamma-butyrolactone) and copolymer thereof UNIV HUAIHUA 2013-09-18 CN disclosed
EP-0722960-B1 Copolymers for preparing cast glass, or molding materials for preparing heat stable shaped articles AGOMER GES MIT BESCHRAENKTER H (DE) 1999-06-02 EP disclosed
US-5880235-A POLYMER PREPARED BY COPOLYMERIZING ALPHA-METHYLENE-GAMMA-BUTYROLACTONE AND VINYLICALLY UNSATURATED MONOMER AGOMER GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1999-03-09 US disclosed
EP-0722960-A2 Copolymers for preparing cast glass, or molding materials for preparing heat stable shaped articles Degussa Aktiengesellschaft (DE) 1996-07-24 EP disclosed