SCHEMBL8396299

SCHEMBL8396299

COc1ccccc1NCc1nc2c(Cl)c(Cl)ccc2s1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.43
MAPT P10636 6/20 0.42
KMT2A Q03164 6/20 0.42
ALDH1A1 P00352 5/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 5/20 0.40
LMNA P02545 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
GLA P06280 1/20 0.40
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
POLB P06746 2/20 0.40
GAA P10253 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
AKR1B1 P15121 1/20 0.39
HTT P42858 2/20 0.39
PKM P14618 1/20 0.39
LRRK2 Q5S007 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8398150 0.85 MEN1 (0.46) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8396286 0.84 KMT2A (0.43) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8400270 0.82 MAPT (0.41) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8396281 0.81 KMT2A (0.43) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8395401 0.81 KMT2A (0.43) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8395550 0.81 L3MBTL1 (0.44) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8396276 0.78 MEN1 (0.47) MAPTKMT2ASMN1; SMN2MEN1LMNA
SCHEMBL8400276 0.76 MEN1 (0.42) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8398024 0.74 MEN1 (0.44) MAPTKMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8395413 0.74 NPC1 (0.44) MAPTKMT2AALDH1A1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0647636-B1 BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF SENJU PHARMA CO (JP) 1999-06-09 EP disclosed
US-5532257-A ENZYME INHIBITOR SENJU PHARMACEUTICAL CO., LTD (JP) 1996-07-02 US disclosed
EP-0647636-A1 BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Senju Pharmaceutical Co., Ltd. (JP) 1995-04-12 EP disclosed