Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394917 | 1.00 | EPHX1 (0.49) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL8395020 | 0.98 | SIGMAR1 (0.48) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL8392409 | 0.94 | SIGMAR1 (0.44) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL8396544 | 0.90 | SIGMAR1 (0.40) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL8393790 | 0.88 | EPHX1 (0.61) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL8391133 | 0.88 | EPHX1 (0.61) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL8395518 | 0.85 | EPHX1 (0.58) | EPHX1SIGMAR1HRH4HRH3ALDH1A1 | |
| SCHEMBL11306651 | 0.84 | CYP2D6 (0.50) | EPHX1SIGMAR1HRH4HRH3CYP1A2 | |
| SCHEMBL8078349 | 0.82 | TSHR (0.47) | EPHX1SIGMAR1HRH4HRH3CYP1A2 | |
| SCHEMBL8392716 | 0.82 | KDM4E (0.50) | EPHX1SIGMAR1CYP1A2HPGDBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |