Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399118 | 0.91 | AKR1B1 (0.43) | AKR1B1LTB4R2NPC1 | |
| SCHEMBL8397936 | 0.90 | AKR1B1 (0.48) | AKR1B1LMNA | |
| SCHEMBL8395765 | 0.89 | AKR1B1 (0.48) | AKR1B1HDAC6 | |
| SCHEMBL8397923 | 0.89 | AKR1B1 (0.42) | AKR1B1LTB4R2NPC1ALDH1A1LMNA | |
| SCHEMBL8398031 | 0.89 | AKR1B1 (0.42) | AKR1B1LTB4R2RXRARXRBRXRG | |
| SCHEMBL8399334 | 0.88 | SMN1; SMN2 (0.40) | AKR1B1HDAC6LTB4R2NPC1ALDH1A1 | |
| SCHEMBL8399483 | 0.87 | HDAC6 (0.39) | HDAC6LTB4R2RXRARXRBRXRG | |
| SCHEMBL8399158 | 0.87 | AKR1B1 (0.41) | AKR1B1LTB4R2LMNA | |
| SCHEMBL8400191 | 0.86 | AKR1B1 (0.39) | AKR1B1HDAC6LTB4R2LMNA | |
| SCHEMBL8398694 | 0.86 | AKR1B1 (0.40) | AKR1B1LTB4R2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647636-B1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | SENJU PHARMA CO (JP) | 1999-06-09 | — | — | EP | disclosed |
| US-5532257-A | ENZYME INHIBITOR | SENJU PHARMACEUTICAL CO., LTD (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0647636-A1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Senju Pharmaceutical Co., Ltd. (JP) | 1995-04-12 | — | — | EP | disclosed |