Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11594821 | 1.00 | ALDH1A1 (0.59) | ALDH1A1CYP3A4EPHX2EPHX1HRH4 | |
| SCHEMBL11596858 | 1.00 | ALDH1A1 (0.59) | ALDH1A1CYP3A4EPHX2EPHX1HRH4 | |
| SCHEMBL11594299 | 1.00 | ALDH1A1 (0.59) | ALDH1A1CYP3A4EPHX2EPHX1HRH4 | |
| SCHEMBL20204692 | 0.98 | ALDH1A1 (0.62) | ALDH1A1CYP3A4EPHX2EPHX1HRH4 | |
| SCHEMBL11596495 | 0.93 | EPHX1 (0.58) | EPHX2EPHX1KDM4ECASP2TRPV1 | |
| SCHEMBL11593203 | 0.93 | EPHX1 (0.58) | EPHX2EPHX1KDM4ECASP2TRPV1 | |
| SCHEMBL11596178 | 0.93 | EPHX1 (0.58) | EPHX2EPHX1KDM4ECASP2TRPV1 | |
| SCHEMBL11594414 | 0.93 | EPHX1 (0.58) | EPHX2EPHX1KDM4ECASP2TRPV1 | |
| SCHEMBL11595110 | 0.93 | EPHX1 (0.58) | EPHX2EPHX1KDM4ECASP2TRPV1 | |
| SCHEMBL8979287 | 0.93 | EPHX1 (0.58) | EPHX2EPHX1KDM4ECASP2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| US-5153331-A | Reacting 6-epoxyethyl-3-oxatricyclo 3.2.1.0(2,4)!octane with a thiocyanate salt and/or a thiourea | NIPPON OIL COMPANY, LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0452092-A2 | 6-Epithioethyl-3-oxatricyclo (3.2.1.02.4) octane and process for preparation thereof | NIPPON OIL CO. LTD. (JP) | 1991-10-16 | — | — | EP | disclosed |