Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398045 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AJAK2ALDH1A1 | |
| SCHEMBL8400310 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1ALDH1A1AKR1B1LMNA | |
| SCHEMBL8395578 | 0.90 | AKR1B1 (0.39) | NPC1RAB9AJAK2ALDH1A1HTT | |
| SCHEMBL8399196 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1ALDH1A1AKR1B1KMT2A | |
| SCHEMBL8396319 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AJAK2ALDH1A1 | |
| SCHEMBL8396242 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AAKR1B1KMT2A | |
| SCHEMBL8398046 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL8398973 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTAKR1B1LMNAMAOB | |
| SCHEMBL8399715 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AJAK2ALDH1A1 | |
| SCHEMBL8398030 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AJAK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647636-B1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | SENJU PHARMA CO (JP) | 1999-06-09 | — | — | EP | disclosed |
| US-5532257-A | ENZYME INHIBITOR | SENJU PHARMACEUTICAL CO., LTD (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0647636-A1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Senju Pharmaceutical Co., Ltd. (JP) | 1995-04-12 | — | — | EP | disclosed |