Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392454 | 0.98 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL8395899 | 0.88 | — | — | |
| SCHEMBL3068941 | 0.83 | ALDH1A1 (0.64) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL3071756 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL8395648 | 0.77 | ALDH1A1 (0.56) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL8397114 | 0.77 | ALDH1A1 (0.56) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL3075448 | 0.77 | ALDH1A1 (0.50) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL3061207 | 0.77 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4TP53SMN1; SMN2NPC1 | |
| SCHEMBL3071754 | 0.77 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4TP53LMNAGAA | |
| SCHEMBL8392449 | 0.74 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4TP53LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |