Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.67 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.66 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391175 | 0.89 | AGTR1 (0.67) | PPARGAGTR1AGTR2 | |
| SCHEMBL8394634 | 0.89 | PPARG (0.53) | PPARGAGTR1AGTR2 | |
| SCHEMBL9042509 | 0.88 | PPARG (0.51) | PPARGAGTR1AGTR2 | |
| SCHEMBL8391704 | 0.87 | AGTR1 (0.73) | PPARGAGTR1AGTR2 | |
| SCHEMBL8396606 | 0.84 | AGTR1 (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9042140 | 0.84 | PPARG (0.46) | PPARGAGTR1AGTR2 | |
| SCHEMBL8395682 | 0.82 | AGTR1 (0.72) | PPARGAGTR1AGTR2 | |
| SCHEMBL8394944 | 0.81 | AGTR1 (0.70) | PPARGAGTR1AGTR2 | |
| SCHEMBL8393824 | 0.81 | AGTR1 (0.70) | PPARGAGTR1AGTR2 | |
| SCHEMBL19342750 | 0.80 | PPARG (1.00) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |