Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25721689 | 0.90 | SYK (0.55) | CYP2D6SYKCTSKATMCTSL | |
| SCHEMBL2493028 | 0.88 | ABCB1 (0.54) | CTSKELANEPRTN3ATMCTSL | |
| SCHEMBL2391974 | 0.86 | CTSL (0.48) | CTSKELANEPRTN3ATMCTSL | |
| SCHEMBL13303244 | 0.86 | CTSL (0.48) | CTSKELANEPRTN3ATMCTSL | |
| SCHEMBL3339842 | 0.85 | ATM (0.52) | CTSKELANEPRTN3ATMCTSL | |
| SCHEMBL3338883 | 0.85 | ATM (0.52) | CTSKELANEPRTN3ATMCTSL | |
| SCHEMBL3274393 | 0.85 | ATM (0.52) | CTSKELANEPRTN3ATMCTSL | |
| SCHEMBL8972112 | 0.84 | SYK (0.58) | SYKCTSKELANEATMCTSL | |
| SCHEMBL12203687 | 0.84 | SYK (0.58) | SYKCTSKELANEATMCTSL | |
| SCHEMBL27658167 | 0.83 | SYK (0.55) | SYKCTSKKLK5ELANEATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939527-A | SYNTHETIC OLIGOPEPTIDE WITH BIOLOGICAL ACTIVITY OF DOLASTATIN FROM SEA HARE | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-17 | — | — | US | disclosed |
| EP-0915908-A1 | DOLASTATIN PENTAPEPTIDE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-05-19 | — | — | EP | disclosed |
| US-5741892-A | Pentapeptides as antitumor agents | BASF AKTIENGESELLSCHAFT (DE) | 1998-04-21 | — | — | US | disclosed |
| WO-1998004581-A1 | DOLASTATIN PENTAPEPTIDE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-05 | — | — | WO | disclosed |