Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377064 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1CYSLTR2CYSLTR1YAP1 | |
| SCHEMBL8398113 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1CYSLTR2CYSLTR1YAP1 | |
| SCHEMBL7328301 | 0.82 | NPC1 (0.41) | KMT2AL3MBTL1YAP1RAB9ASMN1; SMN2 | |
| SCHEMBL8654091 | 0.82 | NPC1 (0.41) | KMT2AL3MBTL1YAP1RAB9ASMN1; SMN2 | |
| SCHEMBL8650717 | 0.82 | NPC1 (0.41) | KMT2AL3MBTL1YAP1RAB9ASMN1; SMN2 | |
| SCHEMBL7337139 | 0.82 | NPC1 (0.41) | KMT2AL3MBTL1YAP1RAB9ASMN1; SMN2 | |
| SCHEMBL7375317 | 0.80 | HRH3 (0.48) | KMT2ACYSLTR2CYSLTR1RAB9ANPC1 | |
| SCHEMBL7375323 | 0.80 | HRH3 (0.48) | KMT2ACYSLTR2CYSLTR1RAB9ANPC1 | |
| SCHEMBL7375321 | 0.80 | HRH3 (0.48) | KMT2ACYSLTR2CYSLTR1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL8395630 | 0.79 | HRH3 (0.47) | KMT2ACYSLTR2CYSLTR1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752981-B1 | SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | disclosed |
| US-5817698-A | Substituted cycloalkylamine derivatives and their use as calcium channel antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-10-06 | — | — | US | disclosed |