SCHEMBL8399082

SCHEMBL8399082

COc1ccc(C(C#N)=Cc2cccc(Cl)c2)cc1OC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
HIF1A Q16665 1/20 0.55
EGFR P00533 1/20 0.55
PDGFRB P09619 1/20 0.55
PDGFRA P16234 1/20 0.55
TUBB4A P04350 4/20 0.52
TUBB P07437 4/20 0.52
TUBA3C P0DPH7 4/20 0.52
TUBA1B P68363 4/20 0.52
TUBA4A P68366 4/20 0.52
TUBB4B P68371 4/20 0.52
TUBB3 Q13509 4/20 0.52
TUBB2A Q13885 4/20 0.52
TUBB8 Q3ZCM7 4/20 0.52
TUBA3E Q6PEY2 4/20 0.52
TUBA1A Q71U36 4/20 0.52
TUBA1C Q9BQE3 4/20 0.52
TUBB6 Q9BUF5 4/20 0.52
TUBB2B Q9BVA1 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8399079 1.00 RECQL (0.55) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL9244716 0.90 RECQL (0.65) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4998847 0.87 TUBB4A (0.57) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4998844 0.87 TUBB4A (0.57) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4821934 0.86 PDE4A (0.59) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL8397000 0.86 HIF1A (0.56) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL8397001 0.86 HIF1A (0.56) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4821938 0.86 PDE4A (0.59) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL8400485 0.85 TUBB4A (0.58) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL8400484 0.85 TUBB4A (0.58) RECQLSMN1; SMN2HIF1AEGFRPDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640586-B1 STILBENE DERIVATIVE AND STILBENE ANALOG DERIVATIVE, AND USE THEREOF MORINAGA MILK INDUSTRY CO LTD (JP) 1999-06-09 EP disclosed
US-5589506-A ENZYME INHIBITORS FOR LIPOXYGENASE MORINAGA MILK INDUSTRY CO., LTD. (JP) 1996-12-31 US disclosed
EP-0640586-A1 STILBENE DERIVATIVE AND STILBENE ANALOG DERIVATIVE, AND USE THEREOF MORINAGA MILK INDUSTRY CO., LTD. (JP) 1995-03-01 EP disclosed