SCHEMBL8399095

SCHEMBL8399095

Cc1ccc2c(c1)C(=O)CCC2c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.49
ALDH1A1 P00352 1/20 0.49
ALDH2 P05091 1/20 0.49
KDM4E B2RXH2 1/20 0.44
MAOB P27338 3/20 0.43
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
SLC6A3 Q01959 2/20 0.43
DDB1 Q16531 1/20 0.41
CRBN Q96SW2 1/20 0.41
GAA P10253 1/20 0.39
ELANE P08246 1/20 0.39
PDGFRA P16234 1/20 0.38
PRKACA P17612 1/20 0.38
KDR P35968 1/20 0.38
CDK8 P49336 1/20 0.38
CDK9 P50750 1/20 0.38
ROCK1 Q13464 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
DYRK1B Q9Y463 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31598939 0.91 SLC6A2 (0.41) CYP19A1ALDH1A1ALDH2MAOBSLC6A2
SCHEMBL8402135 0.91 SLC6A2 (0.41) CYP19A1ALDH1A1ALDH2MAOBSLC6A2
SCHEMBL8920465 0.88 CYP19A1 (0.50) CYP19A1ALDH1A1ALDH2KDM4EMAOB
SCHEMBL15354259 0.86 ALDH1A1 (0.60) CYP19A1ALDH1A1ALDH2KDM4EMAOB
SCHEMBL15354258 0.86 ALDH1A1 (0.60) CYP19A1ALDH1A1ALDH2KDM4EMAOB
SCHEMBL15354256 0.86 ALDH1A1 (0.60) CYP19A1ALDH1A1ALDH2KDM4EMAOB
SCHEMBL8402114 0.84 DDB1 (0.49) CYP19A1ALDH1A1ALDH2KDM4EDDB1
SCHEMBL8922065 0.81 CYP19A1 (0.47) CYP19A1ALDH1A1KDM4EMAOBSLC6A2
SCHEMBL8402191 0.81 SLC6A2 (0.47) ALDH1A1ALDH2KDM4ESLC6A2SLC6A4
SCHEMBL19380843 0.80 DDB1 (0.47) CYP19A1ALDH1A1KDM4EDDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0711283-B1 TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS PFIZER (US) 1999-06-16 EP disclosed
US-5643904-A Substituted hexahdryoazepinones and tetrahydrobenzazepinones PFIZER INC. (US) 1997-07-01 US disclosed
US-5618811-A Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists PFIZER INC. (US) 1997-04-08 US disclosed
EP-0711283-A1 TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS PFIZER INC. (US) 1996-05-15 EP disclosed
US-5484917-A FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY PFIZER INC. (US) 1996-01-16 US disclosed
WO-1995003281-A1 TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS PFIZER INC. (US) 1995-02-02 WO disclosed
EP-0625145-A1 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS PFIZER INC. (US) 1994-11-23 EP disclosed
WO-1993015059-A1 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS PFIZER INC. (US) 1993-08-05 WO disclosed