SCHEMBL8399349

SCHEMBL8399349

COCC(=O)c1ccccc1.[NaH]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.54
RAB9A P51151 4/20 0.54
MAPT P10636 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
KMT2A Q03164 4/20 0.54
MEN1 O00255 3/20 0.54
TDP1 Q9NUW8 3/20 0.54
MAPK1 P28482 2/20 0.54
HPGD P15428 2/20 0.54
KDM4E B2RXH2 1/20 0.54
CYP3A4 P08684 1/20 0.54
ALOX15 P16050 1/20 0.54
CES1 P23141 1/20 0.54
LMNA P02545 2/20 0.53
POLB P06746 2/20 0.53
ALDH1A1 P00352 3/20 0.50
GSK3B P49841 2/20 0.50
TSHR P16473 1/20 0.50
TRPA1 O75762 1/20 0.50
HIF1A Q16665 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL28216395 0.98 KMT2A (0.56) NPC1RAB9AMAPTSMN1; SMN2KMT2A
SCHEMBL54072 0.98 KMT2A (0.56) NPC1RAB9AMAPTSMN1; SMN2KMT2A
Hydrochloric Acid SCHEMBL27547476 0.96 NPC1 (0.54) NPC1RAB9AMAPTSMN1; SMN2KMT2A
Formaldehyde SCHEMBL28218175 0.94 NPC1 (0.53) NPC1RAB9AMAPTSMN1; SMN2KMT2A
Anisole SCHEMBL4124697 0.88 L3MBTL1 (0.57) NPC1RAB9AMAPTSMN1; SMN2KMT2A
SCHEMBL31414407 0.86 MAPT (0.63) NPC1RAB9AMAPTSMN1; SMN2KMT2A
SCHEMBL28874159 0.84 CTNNB1 (0.54) NPC1RAB9AMAPTSMN1; SMN2KMT2A
SCHEMBL28441720 0.83 ERCC5 (0.60) NPC1RAB9AMAPTSMN1; SMN2LMNA
SCHEMBL7290567 0.83 CA1 (0.54) NPC1RAB9AMAPTSMN1; SMN2KMT2A
SCHEMBL23755153 0.82 KMT2A (0.59) NPC1RAB9AMAPTSMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5968963-A ADMINISTERING 1-(PHENYLMETHYL)-4-UNDECYL-5H-TETRAZOLE-5-IMINE TO PREVENT OR TREAT HYPERCHOLESTEROLEMIA WARNER-LAMBERT COMPANY (US) 1999-10-19 US disclosed
EP-0769005-A2 PLA 2? INHIBITORS AND THEIR USE FOR INHIBITION OF INTESTINAL CHOLESTEROL ABSORPTION WARNER-LAMBERT COMPANY (US) 1997-04-23 EP disclosed
US-5578639-A ANTICHOLESTEROL AGENTS WARNER-LAMBERT COMPANY (US) 1996-11-26 US disclosed
US-5504073-A ADMINISTERING A METHYL-(2-(HEXADECYLOXY)-PHENYL) METHYL ESTER PHOSPHONIC ACID TO TREAT ATHEROSCLEROSIS; PHOSPHOLIPASE A2 INHIBITION WARNER-LAMBERT COMPANY (US) 1996-04-02 US disclosed
WO-1996001253-A2 PLA2 INHIBITORS AND THEIR USE FOR INHIBITION OF INTESTINAL CHOLESTEROL ABSORPTION WARNER-LAMBERT COMPANY (US) 1996-01-18 WO disclosed