SCHEMBL8400192

SCHEMBL8400192

CC(C)(NC(=O)c1cccc(C#N)c1)C(=O)C(Br)Br

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.57
GRM5 P41594 2/20 0.47
ALDH1A1 P00352 1/20 0.46
GPR139 Q6DWJ6 1/20 0.45
ANO1 Q5XXA6 1/20 0.43
S1PR3 Q99500 2/20 0.42
IRAK4 Q9NWZ3 1/20 0.42
VNN1 O95497 1/20 0.41
KAT6A Q92794 1/20 0.41
PSMB8 P28062 1/20 0.41
PSMB5 P28074 1/20 0.41
ABCC9 O60706 1/20 0.40
ABCC8 Q09428 1/20 0.40
KCNJ11 Q14654 1/20 0.40
KCNJ8 Q15842 1/20 0.40
GAA P10253 1/20 0.40
S1PR1 P21453 1/20 0.40
PDK1 Q15118 1/20 0.40
PDK2 Q15119 1/20 0.40
PDK3 Q15120 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13701651 0.82 ANO1 (0.58) GSK3BGRM5ALDH1A1GPR139ANO1
SCHEMBL8400015 0.81 SMN1; SMN2 (0.54) GRM5ALDH1A1GAA
SCHEMBL8403994 0.81 HDAC8 (0.53)
SCHEMBL8400004 0.80 TP53BP1 (0.48) GRM5ALDH1A1KAT6AGAA
SCHEMBL8400002 0.77 MRGPRX4 (0.40) ALDH1A1KAT6AGAA
SCHEMBL13702400 0.77 GSK3B (0.50) GSK3BGRM5ALDH1A1GPR139ANO1
SCHEMBL8403984 0.75 CA2 (0.48) ALDH1A1KAT6AGAA
SCHEMBL3819152 0.74 GRM5 (0.58) GSK3BGRM5ALDH1A1GPR139S1PR3
SCHEMBL6784031 0.74 GSK3B (1.00) GSK3BGRM5ALDH1A1GPR139S1PR3
SCHEMBL3610584 0.73 KAT6A (0.59) GSK3BGRM5ALDH1A1GPR139S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5859063-A Use of certain N-acetonylbenzamides as fungicides ROHM AND HAAS COMPANY (US) 1999-01-12 US disclosed
US-5629346-A LOW TOXICITY ROHM AND HAAS COMPANY (US) 1997-05-13 US disclosed
US-4822902-A LOW PHYTOTOXICITY ROHM AND HAAS COMPANY (US) 1989-04-18 US disclosed
EP-0173453-B1 SUBSTITUTED N-ACETONYLBENZAMIDES AND THEIR USE AS FUNGICIDES ROHM AND HAAS COMPANY (US) 1988-07-13 EP disclosed
EP-0173453-A1 Substituted N-acetonylbenzamides and their use as fungicides ROHM AND HAAS COMPANY (US) 1986-03-05 EP disclosed