Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838214 | 0.86 | GCK (0.45) | GCKKCNH2SMN1; SMN2 | |
| SCHEMBL840082 | 0.81 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL3299297 | 0.81 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL838666 | 0.81 | GCK (0.57) | GCKKCNH2 | |
| SCHEMBL840028 | 0.79 | GCK (0.54) | GCKKCNH2 | |
| SCHEMBL840030 | 0.78 | GCK (0.51) | GCKKCNH2 | |
| SCHEMBL840029 | 0.77 | GCK (0.40) | GCKKCNH2 | |
| SCHEMBL838403 | 0.72 | GCK (0.54) | GCKKCNH2 | |
| SCHEMBL838402 | 0.72 | GCK (0.54) | GCKKCNH2 | |
| SCHEMBL839291 | 0.72 | XDH (0.36) | MAPTSMN1; SMN2LMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |