Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | MELK | Q14680 | 2/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15181344 | 0.84 | PLK1 (0.49) | CDK2CDK4CAMK2DFLT3DAPK3 | |
| SCHEMBL84379 | 0.82 | AURKA (0.67) | DYRK1ACLK4MAPK8CLK2KDR | |
| SCHEMBL91451 | 0.81 | SMN1; SMN2 (0.67) | CDK2CDK4FLT3DAPK3PRKD3 | |
| SCHEMBL84484 | 0.81 | EGFR (0.69) | CDK2CDK4GSK3BCDK5DYRK1A | |
| SCHEMBL15181351 | 0.81 | CDK5 (0.51) | CDK2CDK4FLT3GSK3BCDK5 | |
| SCHEMBL84027 | 0.79 | IGF1R (0.59) | CDK2GSK3BPRKACAPIK3CAPIK3CG | |
| SCHEMBL3951217 | 0.78 | LMNA (0.53) | CDK2CDK4FLT3DAPK3PRKD3 | |
| SCHEMBL30847380 | 0.78 | CDK2 (0.55) | CDK2CDK4FLT3DAPK3PRKD3 | |
| SCHEMBL27111928 | 0.78 | CDK2 (0.55) | CDK2CDK4FLT3DAPK3PRKD3 | |
| SCHEMBL20004013 | 0.77 | PIK3CG (0.56) | CDK2CDK4FLT3DAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | CDK2 20/4885CDK4 12/4885CAMK2D 581/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | CDK2 34/4885CDK4 20/4885CAMK2D 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.