SCHEMBL8400408

SCHEMBL8400408

CCCCC[C@H]1CC[C@H]([Si@H]2CC[C@H](c3ccc(F)cc3)CC2)CC1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.37
MAPT P10636 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
MAPK1 P28482 1/20 0.36
SPHK1 Q9NYA1 3/20 0.35
TP53 P04637 4/20 0.35
POLB P06746 1/20 0.35
ESR2 Q92731 1/20 0.33
GAA P10253 1/20 0.33
GRM2 Q14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8400407 1.00 CYP2C9 (0.37) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8400406 1.00 CYP2C9 (0.37) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8395247 0.96 CYP2C9 (0.38) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8395243 0.96 CYP2C9 (0.38) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8395245 0.96 CYP2C9 (0.38) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8398649 0.91 CYP2C9 (0.46) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8398660 0.91 CYP2C9 (0.46) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8398656 0.91 CYP2C9 (0.46) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8019269 0.87 CYP2C9 (0.43) CYP2C9MAPTMEN1KMT2AALDH1A1
SCHEMBL8019267 0.87 CYP2C9 (0.43) CYP2C9MAPTMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5951913-A Liquid crystal compositions comprising silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-09-14 US disclosed
EP-0630903-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 1999-06-02 EP disclosed