Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7635074 | 0.80 | DCUN1D1 (0.71) | DCUN1D1HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL2629350 | 0.78 | SMN1; SMN2 (0.58) | CYP1A2CYP3A4CYP2C19HPGDLMNA | |
| SCHEMBL11598851 | 0.76 | SMN1; SMN2 (0.87) | CYP1A2CYP3A4HPGDLMNASMN1; SMN2 | |
| SCHEMBL5787498 | 0.75 | ALDH1A1 (0.65) | CYP1A2CYP3A4LMNASMN1; SMN2MAPT | |
| SCHEMBL1233176 | 0.75 | SMN1; SMN2 (0.58) | CYP1A2CYP3A4CYP2C19HPGDSMN1; SMN2 | |
| SCHEMBL2251043 | 0.73 | SMN1; SMN2 (0.87) | CYP1A2CYP3A4CYP2C19HPGDLMNA | |
| SCHEMBL25957505 | 0.73 | DCUN1D1 (0.66) | DCUN1D1NPC1POLBKDM4ERAB9A | |
| SCHEMBL16661201 | 0.73 | DCUN1D1 (0.57) | DCUN1D1CYP1A2CYP3A4CYP2C19MAPT | |
| SCHEMBL17280142 | 0.72 | SMN1; SMN2 (0.73) | HPGDSMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL15452340 | 0.72 | SMN1; SMN2 (0.73) | LMNASMN1; SMN2NPC1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36374-E | 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists | H. LUNDBECK, A/S (DK) | 1999-11-02 | — | — | US | disclosed |
| EP-0296721-B1 | HETEROCYCLIC COMPOUNDS | H. LUNDBECK A/S (DK) | 1993-06-23 | — | — | EP | disclosed |
| US-4925858-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1990-05-15 | — | — | US | disclosed |
| US-4866077-A | TREATMENT OF NERVOUS SYSTEM DISORDERS SUCH AS ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1989-09-12 | — | — | US | disclosed |
| EP-0296721-A2 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1988-12-28 | — | — | EP | disclosed |