SCHEMBL8400520

SCHEMBL8400520

Cc1cccc(CCCCCCCCCCc2cccc(C)c2O)c1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.54
ALOX5 P09917 1/20 0.49
PTGS2 P35354 1/20 0.49
TRPA1 O75762 1/20 0.48
TYR P14679 1/20 0.47
GABRA1 P14867 2/20 0.43
GABRB2 P47870 2/20 0.43
BID P55957 3/20 0.42
MCL1 Q07820 3/20 0.42
BCL2L1 Q07817 2/20 0.42
BAK1 Q16611 2/20 0.42
KAT8 Q9H7Z6 2/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
EP300 Q09472 1/20 0.42
KAT2A Q92830 1/20 0.42
KAT2B Q92831 1/20 0.42
KAT5 Q92993 1/20 0.42
SAE1 Q9UBE0 1/20 0.42
LIPG Q9Y5X9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28362575 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL28362317 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL28362453 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL9317862 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL8591315 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL8398368 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL7178199 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL7171678 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL10475510 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID
SCHEMBL28883593 0.92 ALOX5 (0.60) ALDH1A1ALOX5PTGS2TYRBID

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5859067-A PREPARING BIS(2-HYDROXY-1-NAPHTHYL)DECANE FROM THE CORRESPONDING DIACID; FORMING ACID DICHLORIDE; TREATING WITH 2-NAPHTHOL; REARRANGEMENT; REDUCTION; INHIBITS ACTION OF ADENOSINE TRIPHOSPHATASE ROUFOGALIS BASIL DON (AU) 1999-01-12 US disclosed
US-5741821-A PHENOLIC ENZYME INHIBITORS THE UNIVERSITY OF SYDNEY (AU) 1998-04-21 US disclosed
WO-1994028886-A1 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE THE UNIVERSITY OF SYDNEY (AU) 1994-12-22 WO disclosed