SCHEMBL8400533

SCHEMBL8400533

COc1ccc(/C(C#N)=C/c2ccccc2)cc1OC

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
HIF1A Q16665 1/20 0.57
EGFR P00533 1/20 0.57
PDGFRB P09619 1/20 0.57
PDGFRA P16234 1/20 0.57
TUBB4A P04350 4/20 0.57
TUBB P07437 4/20 0.57
TUBA3C P0DPH7 4/20 0.57
TUBA1B P68363 4/20 0.57
TUBA4A P68366 4/20 0.57
TUBB4B P68371 4/20 0.57
TUBB3 Q13509 4/20 0.57
TUBB2A Q13885 4/20 0.57
TUBB8 Q3ZCM7 4/20 0.57
TUBA3E Q6PEY2 4/20 0.57
TUBA1A Q71U36 4/20 0.57
TUBA1C Q9BQE3 4/20 0.57
TUBB6 Q9BUF5 4/20 0.57
TUBB2B Q9BVA1 4/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8400535 1.00 RECQL (0.57) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL12507433 0.88 RECQL (0.67) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4996875 0.88 RECQL (0.67) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4996892 0.88 RECQL (0.67) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL622670 0.87 TUBB4A (0.53) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL622671 0.87 TUBB4A (0.53) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4998847 0.87 TUBB4A (0.57) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4998844 0.87 TUBB4A (0.57) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4993833 0.87 PTPN7 (0.61) RECQLSMN1; SMN2HIF1AEGFRPDGFRB
SCHEMBL4993841 0.87 PTPN7 (0.61) RECQLSMN1; SMN2HIF1AEGFRPDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640586-B1 STILBENE DERIVATIVE AND STILBENE ANALOG DERIVATIVE, AND USE THEREOF MORINAGA MILK INDUSTRY CO LTD (JP) 1999-06-09 EP disclosed
US-5589506-A ENZYME INHIBITORS FOR LIPOXYGENASE MORINAGA MILK INDUSTRY CO., LTD. (JP) 1996-12-31 US disclosed
EP-0640586-A1 STILBENE DERIVATIVE AND STILBENE ANALOG DERIVATIVE, AND USE THEREOF MORINAGA MILK INDUSTRY CO., LTD. (JP) 1995-03-01 EP disclosed