Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 18/20 | 0.79 |
| ▸ | HTR1B | P28222 | 17/20 | 0.79 |
| ▸ | HTR2A | P28223 | 6/20 | 0.79 |
| ▸ | HTR1A | P08908 | 15/20 | 0.61 |
| ▸ | HTR2C | P28335 | 5/20 | 0.59 |
| ▸ | HTR6 | P50406 | 4/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985970 | 0.88 | HTR1D (0.92) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7803371 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8402123 | 0.87 | HTR1D (0.65) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7525124 | 0.85 | HTR1D (0.66) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL5827584 | 0.84 | HTR1D (0.64) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8179989 | 0.82 | HTR1D (0.58) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8626746 | 0.81 | HTR1D (0.64) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8120074 | 0.81 | HTR1D (0.57) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8122186 | 0.81 | MEN1 (0.60) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8127402 | 0.81 | HTR1D (0.61) | HTR1DHTR1BHTR2AHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5905080-A | Amide and urea derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-05-18 | — | — | US | claimed |
| EP-0714389-B1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-17 | — | — | EP | claimed |
| EP-0714389-A1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-05 | — | — | EP | claimed |
| WO-1995006044-A1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-02 | — | — | WO | claimed |
| US-5905080-A | Amide and urea derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-05-18 | — | — | US | disclosed |
| EP-0714389-B1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-17 | — | — | EP | disclosed |
| EP-0714389-A1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995006044-A1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-02 | — | — | WO | disclosed |