Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.75 |
| ▸ | DRD1 | P21728 | 2/20 | 0.75 |
| ▸ | DRD3 | P35462 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | DRD5 | P21918 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11365759 | 1.00 | DRD2 (0.75) | DRD2DRD1DRD3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL8665681 | 0.99 | DRD2 (0.73) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL11336084 | 0.93 | MAPT (0.76) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL11712364 | 0.90 | DRD2 (0.72) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL11801298 | 0.90 | DRD2 (0.72) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL11712503 | 0.90 | DRD2 (0.72) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL11730898 | 0.90 | DRD2 (0.72) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL11804646 | 0.88 | DRD2 (0.74) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL8639351 | 0.87 | KDM4E (0.68) | DRD2DRD1DRD3KMT2AMEN1 | |
| SCHEMBL876068 | 0.87 | DRD2 (0.69) | DRD2DRD1DRD3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955608-A | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents | ELI LILLY AND COMPANY (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0699673-B1 | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents | LILLY CO ELI (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5731436-A | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents | ELI LILLY AND COMPANY (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0699673-A1 | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |
| US-4298603-A | LOCAL ANESTHETICS | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 1981-11-03 | — | — | US | disclosed |
| EP-0031632-A1 | O-Aminoalkylsalicylates, process for their preparation, and their pharmaceutical compositions | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 1981-07-08 | — | — | EP | disclosed |