Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297119 | 0.92 | NPC1 (0.48) | RAB9ANPC1MMP1MMP9ALDH1A1 | |
| SCHEMBL8405738 | 0.90 | NPC1 (0.48) | ELANERAB9ANPC1MMP1MMP9 | |
| SCHEMBL8403661 | 0.88 | TRPV1 (0.46) | ELANERAB9ANPC1MMP1MMP9 | |
| SCHEMBL7292933 | 0.88 | MGLL (0.44) | ELANERAB9ANPC1MMP1MMP9 | |
| SCHEMBL8401224 | 0.87 | POLB (0.52) | RAB9ANPC1CASP3 | |
| SCHEMBL8401492 | 0.85 | NPC1 (0.47) | ELANERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8405847 | 0.85 | ELANE (0.45) | ELANERAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL7294402 | 0.84 | NAMPT (0.47) | ELANERAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL8405271 | 0.83 | NPC1 (0.53) | TACR3ELANERAB9ANPC1ALDH1A1 | |
| SCHEMBL8403689 | 0.82 | ELANE (0.41) | ELANERAB9ANPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |