SCHEMBL8401190

SCHEMBL8401190

CC(C)[C@H](N)C(=O)O[Si](C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.44
DPP4 P27487 2/20 0.33
SLC1A3 P43003 1/20 0.33
SLC1A2 P43004 1/20 0.33
SLC1A1 P43005 1/20 0.33
FAP Q12884 1/20 0.33
DPP8 Q6V1X1 1/20 0.33
DPP9 Q86TI2 1/20 0.33
DPP7 Q9UHL4 1/20 0.33
LAP3 P28838 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9235726 1.00 SLC7A5 (0.44) SLC7A5DPP4SLC1A3SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL8401187 0.98 SLC7A5 (0.42) SLC7A5DPP4SLC1A3SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL8401189 0.98 SLC7A5 (0.42) SLC7A5DPP4SLC1A3SLC1A2SLC1A1
SCHEMBL17912256 0.83 SLC7A5 (0.38) SLC7A5
SCHEMBL16540478 0.83 SLC7A5 (0.38) SLC7A5
SCHEMBL17912255 0.83 SLC7A5 (0.38) SLC7A5
SCHEMBL13984761 0.80 SLC1A3 (0.39) SLC7A5SLC1A3SLC1A2SLC1A1
SCHEMBL10453588 0.80 SLC1A3 (0.31) SLC7A5SLC1A3SLC1A2SLC1A1
SCHEMBL8404068 0.80 SLC1A3 (0.31) SLC7A5SLC1A3SLC1A2SLC1A1
SCHEMBL9112299 0.80 SLC1A3 (0.31) SLC7A5SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3039068-B1 MOISTURE CURABLE COMPOUND WITH AMINO ACIDS MOMENTIVE PERFORMANCE MAT INC (US) 2020-12-16 EP claimed
US-20160200880-A1 MOISTURE CURABLE COMPOSITION WITH AMINO ACIDS MOMENTIVE PERFORMANCE MATERIALS INC. 2016-07-14 US claimed
EP-3039068-A1 MOISTURE CURABLE COMPOUND WITH AMINO ACIDS Momentive Performance Materials Inc. (US) 2016-07-06 EP claimed
WO-2015031712-A1 MOISTURE CURABLE COMPOUND WITH AMINO ACIDS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-03-05 WO claimed
EP-0636117-A4 METHOD OF ADMINISTERING PYRUVATE AND METHODS OF SYNTHESIZING PYRUVATE PRECURSORS. ABBOTT LAB (US) 1995-07-26 EP claimed
EP-0636117-A1 USE OF PYRUVAMIDE AND SELECTED PYRUVYL-AMINO ACIDS ABBOTT LABORATORIES (US) 1995-02-01 EP claimed
WO-1993021147-A1 METHOD OF ADMINISTERING PYRUVATE AND METHODS OF SYNTHESIZING PYRUVATE PRECURSORS ABBOTT LABORATORIES (US) 1993-10-28 WO claimed
EP-3039068-B1 MOISTURE CURABLE COMPOUND WITH AMINO ACIDS MOMENTIVE PERFORMANCE MAT INC (US) 2020-12-16 EP disclosed
US-9914809-B2 Moisture curable composition with amino acids MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2018-03-13 US disclosed
US-20160200880-A1 MOISTURE CURABLE COMPOSITION WITH AMINO ACIDS MOMENTIVE PERFORMANCE MATERIALS INC. 2016-07-14 US disclosed
EP-3039068-A1 MOISTURE CURABLE COMPOUND WITH AMINO ACIDS Momentive Performance Materials Inc. (US) 2016-07-06 EP disclosed
WO-2015031712-A1 MOISTURE CURABLE COMPOUND WITH AMINO ACIDS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-03-05 WO disclosed
EP-0636117-B1 USE OF PYRUVAMIDE AND SELECTED PYRUVYL-AMINO ACIDS STANKO RONALD T (US) 1999-06-23 EP disclosed
US-5472980-A Reducing insulin resistance in mammals with amino acid derivatives ABBOTT LABORATORIES (US) 1995-12-05 US disclosed
US-5312985-A Reaction of sodium pyruvate with thionyl chloride and oxalyl chloride to form pyruvyl chloride, then reaction with 1,1,1,3,3,3-hexamethyldisilazane and methanol to form pyruvamide ABBOTT LABORATORIES (US) 1994-05-17 US disclosed
US-5283260-A Oral ingesting a pyruvyl-amino acid compound before a glucose tolerance test ABBOTT LABORATORIES (US) 1994-02-01 US disclosed
US-5256697-A Covalently linked pyruvyl-amino compound ABBOTT LABORATORIES 1993-10-26 US disclosed