Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404088 | 0.78 | NR1H2 (0.37) | MAPK1NR1H2ESR2MAPTKDM4E | |
| SCHEMBL8404076 | 0.76 | GPR119 (0.34) | MAPK1NR1H2HTTGRM1GRM5 | |
| SCHEMBL7473234 | 0.75 | GPR119 (0.48) | MAPK1NR1H2ESR2DGAT2GRM1 | |
| SCHEMBL23124004 | 0.75 | MAPK1 (0.40) | MAPK1NR1H2ESR2DGAT2HTT | |
| SCHEMBL30269953 | 0.74 | GPR119 (0.47) | MAPK1NR1H2ESR2DGAT2MAPT | |
| SCHEMBL22441484 | 0.74 | GRM1 (0.48) | MAPK1NR1H2ESR2DGAT2GRM1 | |
| SCHEMBL27157321 | 0.74 | MAPK1 (0.39) | MAPK1NR1H2ESR2DGAT2HTT | |
| SCHEMBL6352947 | 0.74 | MAPK1 (0.49) | MAPK1NR1H2ESR2GRM1GRM5 | |
| SCHEMBL20281789 | 0.73 | ESR2 (0.41) | MAPK1NR1H2ESR2DGAT2GRM5 | |
| SCHEMBL21425261 | 0.73 | ESR2 (0.43) | MAPK1NR1H2ESR2DGAT2GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36374-E | 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists | H. LUNDBECK, A/S (DK) | 1999-11-02 | — | — | US | disclosed |
| EP-0296721-B1 | HETEROCYCLIC COMPOUNDS | H. LUNDBECK A/S (DK) | 1993-06-23 | — | — | EP | disclosed |
| US-4925858-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1990-05-15 | — | — | US | disclosed |
| US-4866077-A | TREATMENT OF NERVOUS SYSTEM DISORDERS SUCH AS ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1989-09-12 | — | — | US | disclosed |
| EP-0296721-A2 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1988-12-28 | — | — | EP | disclosed |