Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | ROS1 | P08922 | 1/20 | 0.30 |
| ▸ | MARK3 | P27448 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18293065 | 0.78 | HTR2A (0.50) | ADRA2APNMTADRA2BADRA2CHTR2A | |
| SCHEMBL8367488 | 0.76 | HTR2A (0.34) | HTR2AHTR2C | |
| SCHEMBL8402505 | 0.76 | BACE1 (0.42) | HTR2AHTR2CHTR2BBACE1 | |
| SCHEMBL3361207 | 0.75 | HTR2A (0.46) | ADRA2APNMTADRA2BADRA2CHTR2A | |
| SCHEMBL15732049 | 0.75 | KDM1A (0.37) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL3162257 | 0.75 | HTR2A (0.36) | ADRA2APNMTADRA2BADRA2CHTR2A | |
| SCHEMBL8116867 | 0.74 | HTR2A (0.36) | ADRA2APNMTADRA2BADRA2CHTR2A | |
| SCHEMBL27617880 | 0.73 | POLB (0.31) | BACE1MEN1POLBKMT2A | |
| SCHEMBL23704762 | 0.71 | HTR2A (0.33) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL27728298 | 0.71 | HTR2A (0.33) | HTR2AHTR2CHTR2BOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920166-B1 | BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN | ARRAY BIOPHARMA INC (US) | 2016-11-02 | — | — | EP | disclosed |
| WO-2014078454-A1 | BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |
| US-7351738-B2 | Substituted ureas and carbamates | ELAN PHARMACEUTICALS, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-20040209925-A1 | Substituted ureas and carbamates | ELAN PHARMACEUTICALS, INC. | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209925-A1 | Substituted ureas and carbamates | BACE1, BACE2, PSEN1 | ADRA2A 3985/4885PNMT 1161/4885ADRA2B 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.