Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.58 |
| ▸ | KIF11 | P52732 | 5/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8402854 | 0.91 | TP53 (0.86) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL765092 | 0.91 | TP53 (0.68) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL8402811 | 0.91 | TP53 (0.68) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL764584 | 0.90 | TP53 (0.67) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL763553 | 0.90 | TP53 (0.84) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL20704585 | 0.89 | TP53 (0.66) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL20704712 | 0.89 | TP53 (0.66) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL904374 | 0.89 | TP53 (0.66) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL764121 | 0.89 | TP53 (0.65) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL8402902 | 0.88 | TP53 (0.65) | TP53MAPTSMN1; SMN2ABCG2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129841-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. | 2012-05-24 | — | — | US | disclosed |
| US-20120129841-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. | 2012-05-24 | — | — | US | disclosed |
| US-20090209521-A9 | Inhibition of VEGF Translation | PTC THERAPEUTICS, INC. | 2009-08-20 | — | — | US | disclosed |
| US-20090209521-A9 | Inhibition of VEGF Translation | PTC THERAPEUTICS, INC. | 2009-08-20 | — | — | US | disclosed |
| US-20080064683-A1 | Inhibition of VEGF Translation | PTC THERAPEUTICS, INC. | 2008-03-13 | — | — | US | disclosed |
| US-20080064683-A1 | Inhibition of VEGF Translation | PTC THERAPEUTICS, INC. | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064683-A1 | Inhibition of VEGF Translation | EIF4E, EIF4EBP1, VEGFA | TP53 854/4885MAPT 4518/4885SMN1; SMN2 4232/4885 |
| US-20120129841-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | VEGFA, FLT4, FLT1 | TP53 61/4885MAPT 4190/4885SMN1; SMN2 3554/4885 |
| US-20090209521-A9 | Inhibition of VEGF Translation | EIF4E, EIF4EBP1, VEGFA | TP53 854/4885MAPT 4518/4885SMN1; SMN2 4232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.