Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL773704 | 0.97 | PTGS1 (0.45) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL7864315 | 0.94 | PTGS1 (0.43) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL30887006 | 0.94 | PTGS1 (0.43) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL32679299 | 0.94 | PTGS1 (0.43) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL747638 | 0.94 | PTGS1 (0.43) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL836069 | 0.94 | PTGS1 (0.43) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL29061145 | 0.94 | PTGS1 (0.43) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL834581 | 0.82 | KDM4E (0.39) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL7050821 | 0.82 | KDM4E (0.39) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL834156 | 0.82 | LMNA (0.35) | PTGS1PDE4ALMNASLC6A6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902610-A | ADMINISTERING WITH OR WITHOUT CISPLATIN IN THE SAME FORMULATION, TO REDUCE TOXIC SIDE EFFECTS OF CISPLATIN IN CANCER THERAPY AND POTENTIATE ITS ANTITUMOR ACTIVITY | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-05-11 | — | — | US | disclosed |
| US-5866617-A | AQUEOUS SOLUTION FOR ADMINISTRATION TO PATIENTS ALSO RECEIVING CISPLATIN; REDUCED SIDE EFFECTS, INCREASED ANTITUMOR ACTIVITY | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5866615-A | LYOPHILIZED FORMULATION WITH ANTICANCER AGENTS; REDUCED SIDE EFFECTS, INCREASED ACTIVITY | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5866169-A | LYOPHILIZED FORMULATION WITH CISPLATIN; REDUCED SIDE EFFECTS, INCREASED ANTITUMOR ACTIVITY | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5789000-A | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1998-08-04 | — | — | US | disclosed |