Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403210 | 1.00 | ALDH1A1 (0.39) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8400995 | 0.80 | ALDH1A1 (0.51) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8920864 | 0.80 | HPGD (0.44) | MAPTSMN1; SMN2KMT2ANPSR1MEN1 | |
| SCHEMBL8920861 | 0.80 | HPGD (0.44) | MAPTSMN1; SMN2KMT2ANPSR1MEN1 | |
| SCHEMBL8402982 | 0.77 | NPC1 (0.35) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8402981 | 0.77 | NPC1 (0.35) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8402475 | 0.77 | KDM4E (0.31) | RAB9ANPC1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL8402477 | 0.77 | KDM4E (0.31) | RAB9ANPC1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL8398673 | 0.74 | SLC6A2 (0.38) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8399422 | 0.72 | SLC6A2 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |