Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764011 | 0.88 | KIF11 (0.46) | KIF11MAPTMEN1KMT2ATP53 | |
| SCHEMBL8403133 | 0.85 | KIF11 (0.48) | KIF11MAPTMEN1KMT2ATP53 | |
| SCHEMBL763430 | 0.83 | TP53 (0.61) | KIF11MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL764680 | 0.83 | KIF11 (0.63) | KIF11MAPTTP53LMNAABCG2 | |
| SCHEMBL763590 | 0.81 | KIF11 (0.55) | KIF11MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL763736 | 0.80 | KIF11 (0.57) | KIF11MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL8402912 | 0.79 | KIF11 (0.63) | KIF11MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL765137 | 0.78 | ABCG2 (0.56) | KIF11MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL8402978 | 0.77 | KIF11 (0.55) | KIF11MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL13336356 | 0.76 | KIF11 (0.53) | KIF11MAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129841-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. | 2012-05-24 | — | — | US | disclosed |
| US-20120129841-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129841-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | VEGFA, FLT4, FLT1 | KIF11 2890/4885MAPT 4190/4885MEN1 2762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.