Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.50 |
| ▸ | ACP1 | P24666 | 3/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403332 | 0.93 | ESR1 (0.54) | ESR1ESR2ACP1SMARCA2 | |
| SCHEMBL8519431 | 0.92 | ESR1 (0.52) | ESR1ESR2KDR | |
| SCHEMBL8399936 | 0.90 | ESR1 (0.53) | ESR1ESR2ACP1SMARCA2KDR | |
| SCHEMBL8403143 | 0.89 | ACP1 (0.55) | ESR1ESR2ACP1SMARCA2 | |
| SCHEMBL8399903 | 0.89 | ACP1 (0.49) | ESR1ESR2ACP1 | |
| SCHEMBL8403321 | 0.88 | ESR1 (0.52) | ESR1ESR2ACP1 | |
| SCHEMBL8401756 | 0.87 | ESR1 (0.51) | ESR1ESR2ACP1 | |
| SCHEMBL8403805 | 0.86 | ESR1 (0.57) | ESR1ESR2ACP1SMARCA2 | |
| SCHEMBL8399890 | 0.85 | ESR1 (0.45) | ESR1ESR2KDR | |
| SCHEMBL8400253 | 0.84 | ESR1 (0.47) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |