Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399014 | 0.83 | DDB1 (0.55) | CRBNDDB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8398580 | 0.80 | SLC6A2 (0.43) | CRBNDDB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3053841 | 0.79 | DDB1 (0.65) | CRBNDDB1SMN1; SMN2 | |
| SCHEMBL8402191 | 0.77 | SLC6A2 (0.47) | CRBNDDB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24548362 | 0.76 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL8921539 | 0.75 | DDB1 (0.55) | CRBNDDB1 | |
| SCHEMBL8402142 | 0.74 | THRB (0.50) | CRBNDDB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8922488 | 0.72 | DDB1 (0.55) | CRBNDDB1LMNA | |
| SCHEMBL26296845 | 0.72 | CRBN (0.61) | CRBNDDB1 | |
| SCHEMBL25935699 | 0.72 | CRBN (0.65) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0711283-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995003281-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-02-02 | — | — | WO | disclosed |