Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 11/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.67 |
| ▸ | C1S | P09871 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404520 | 0.80 | PRSS1 (1.00) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL8404521 | 0.79 | PARP1 (0.48) | PRSS1PRSS3PRSS2 | |
| Hydrochloric Acid SCHEMBL5118627 | 0.78 | PRSS1 (0.95) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL10144259 | 0.77 | PRSS1 (0.69) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL10143065 | 0.77 | PRSS1 (0.69) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL27569975 | 0.76 | PRSS1 (0.35) | PRSS1PRSS3PRSS2 | |
| SCHEMBL8147309 | 0.75 | PRSS1 (0.67) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL14099339 | 0.75 | PRSS1 (0.67) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL19269064 | 0.75 | PRSS1 (0.67) | PRSS1PRSS3PRSS2C1SPLAU | |
| SCHEMBL27830208 | 0.74 | HTT (0.53) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727981-B2 | monoamidino-containing compounds having good bioavailability and/or solubility, used as potent and specific inhibitors of blood coagulation in mammals, and as therapeutic agents for disease states characterized by coagulation disorders | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20090131411-A1 | monoamidino-containing compounds having good bioavailability and/or solubility, used as potent and specific inhibitors of blood coagulation in mammals, and as therapeutic agents for disease states characterized by coagulation disorders | MILLENNIUM PHARMACEUTICALS, INC. | 2009-05-21 | — | — | US | disclosed |
| US-20040116399-A1 | Inhibitors of factor Xa | MILLENNIUM PHARMACEUTICALS, INC. | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131411-A1 | monoamidino-containing compounds having good bioavailability and/or solubility, used as potent and specific inhibitors of blood coagulation in mammals, and as therapeutic agents for disease states characterized by coagulation disorders | F12, F2, PIGS | PRSS1 36/4885PRSS3 47/4885PRSS2 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.