Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 10/20 | 0.48 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409959 | 0.89 | PTGER4 (0.53) | GLRA1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL28078446 | 0.85 | GLRA1 (0.60) | BCHEGLRA1 | |
| SCHEMBL8409882 | 0.85 | MRGPRX4 (0.55) | GLRA1 | |
| SCHEMBL8406586 | 0.85 | GLRA1 (0.51) | BCHEGLRA1PTGER1PTGER4PTGER3 | |
| SCHEMBL8406801 | 0.82 | HPGD (0.50) | GLRA1 | |
| SCHEMBL8409057 | 0.82 | HTR1A (0.37) | HTR1ADRD2BCHEGLRA1ABCB1 | |
| SCHEMBL6036279 | 0.81 | GLRA1 (0.54) | GLRA1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL25760547 | 0.81 | GLRA1 (0.45) | BCHEGLRA1 | |
| SCHEMBL8796653 | 0.80 | PTGER4 (0.52) | GLRA1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL29511190 | 0.78 | HTR1A (0.44) | HTR1ADRD2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |
| EP-0778821-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996006822-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1996-03-07 | — | — | WO | disclosed |